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The current results suggest that outcome prediction ability of the HCTS could be significantly enhanced with rapid point-of-care measurement of plasma levels of IL-10 and Aβ40. This may allow the identification of initially neurologically stable patients who, however, are developing severe secondary brain injury that significantly impairs their recovery. To better illuminate the predictive power of biomarkers in patients with CT-positive findings, we also investigated their abilities in distinguishing between patients with complete and incomplete recovery. The best-performing biomarkers were the same as in discrimination of patients with favorable and unfavorable outcomes, but the predictive performance of the HCTS was low. The HCTS was designed to predict functional outcome according to the GOS (13).

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These algorithms may also help alert caregivers of impending seizures at home. 8 , 9 EEG‐based seizure detection and prediction algorithms proposed by studies over the past 5 years have largely relied on publicly available EEG‐based datasets.

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We investigated the advantages and limitations of the characteristics of the EEG datasets. Based on our study, we identified 17 characteristics that make the EEG datasets unique from each other. The generalized model only learns features and biomarkers present in the current group of patients but might fail to highlight or capture important unique characteristics of certain patients outside the group. However, using larger datasets or multiple datasets for a certain study introduces potential complexity if there are differences in the number of channels or structural properties. To further elucidate the outcome prediction performance of the biomarkers, we also studied patients with CT-negative TBIs (comparison study cohort).

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• The Neurovista ictal dataset, made available via Epilepsyecosystem.org, does not fall into any category, since it only consists of multiple recordings of seizure events for patients.
• Regarding the temporal properties of EEG datasets, the length of segments varies across all datasets for both continuous and noncontinuous datasets as shown in Table 8.
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• The data sets generated for this study are available on request to the corresponding author.

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The results presented here suggest that protein biomarkers IL-10 and Aβ40 provide incremental value in outcome prediction when used in combination with the HCTS. In line with this finding, it has been previously reported that most of the clinical studies have not identified a correlation between blood IL-10 levels and GCS scores (33). We have recently reported IL-10 thresholds of 0.38 and 0.44 pg/ml depending on other markers included in the panels for predicting unfavorable outcomes. Correspondingly, when the HCTS is included in the panels, IL-10 thresholds need to be lower to capture patients with low IL-10 levels, low GCS scores, and unfavorable outcomes. The Electroencephalogram (EEG) plays an important role in detecting and localizing seizures, as well as in the diagnosis of epilepsy. 1

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Artifacts such as muscle or eye movement were removed from the continuous recording by visual inspection to form the final dataset from the University of Bonn. 24 In addition to removing artifacts, the EEG segments chosen in the final dataset had to satisfy the criterion of at least weak stationarity. 24

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• Some studies report how they consider one or more of the above characteristics of EEG data to inform the design of the data processing and ML pipelines.
• Comparison of AUCs by the model of DeLong and colleagues demonstrated a statistical difference in the discriminative ability of both Rotterdam and Helsinki scores when compared with Marshall’s classification.
• In addition, the scores were added in a second block to evaluate its increment in the standard model.

TBI, traumatic brain injury; CT, computerized tomography; AUC, area under the curve; CI, confidence interval. CT, computerized tomography; TBI, traumatic brain injury; tSAH, traumatic subarachnoid hemorrhage. The distribution of preictal, ictal, and interictal class in the datasets. JP, RT, AK, MM, IH, H-RM, JT, PK, and OT collected and curated the data. JP drafted the manuscript with critical contributions from RT, RR, and TL.